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Utilizing the GCRLE grant, Munakata and Namekawa will look a lot more carefully at how oocytes are genomically primed and stored for afterwards use. They'll investigate the function of the chromatin remodeler in oocyte survival and fertility.
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This could enable reveal why more mature Girls are more likely to bear small children with chromosomal Issues like Down Syndrome, where an extra duplicate of chromosome 21 finds its way into an oocyte — and afterwards, an embryo.
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“We don’t know the way these cells are managed for decades,” suggests Namekawa. “We want to know The trick of this mechanism.
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Yasuhisa Munakata, a postdoctoral fellow in the school of Organic Sciences, has been given a grant to review how egg cells during the ovary modify eventually.
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